| Post Translational Modifications | Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. |
| Function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. |
| Protein Name | E3 Ubiquitin-Protein Ligase Nrdp1Ring Finger Protein 41Ring-Type E3 Ubiquitin Transferase Nrdp1 |
| Database Links | Reactome: R-HSA-1358803Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Nrdp1 antibodyAnti-Ring Finger Protein 41 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nrdp1 antibodyAnti-RNF41 antibodyAnti-FLRF antibodyAnti-NRDP1 antibodyAnti-SBBI03 antibody |
Information sourced from Uniprot.org
