| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
RNF41 |
| Gene ID: |
10193 |
| Uniprot ID: |
RNF41_HUMAN |
| Immunogen Region: |
1-317 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human RNF41 (NP_005776.1). |
| Immunogen Sequence: |
MGYDVTRFQGDVDEDLICPI CSGVLEEPVQAPHCEHAFCN ACITQWFSQQQTCPVDRSVV TVAHLRPVPRIMRNMLSKLQ IACDNAVFGCSAVVRLDNLM SHLSDCEHNPKRPVTCEQGC GLEMPKDELPNHNCIKHLRS VVQQQQTRIAELEKTSAEHK HQLAEQKRDIQLLKAYMRAI RSVNPNLQNLEETIEYNEIL EWVNSLQPARVTRWGGMIST PDAVLQAVIKRSLVESGCP |
| Tissue Specificity | Detected in ovary, testis and prostate. |
| Post Translational Modifications | Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. |
| Function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. |
| Protein Name | E3 Ubiquitin-Protein Ligase Nrdp1Ring Finger Protein 41Ring-Type E3 Ubiquitin Transferase Nrdp1 |
| Database Links | Reactome: R-HSA-1358803Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Nrdp1 antibodyAnti-Ring Finger Protein 41 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nrdp1 antibodyAnti-RNF41 antibodyAnti-FLRF antibodyAnti-NRDP1 antibodyAnti-SBBI03 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
