| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF19A (639-838) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF19A |
| Gene ID: |
25897 |
| Uniprot ID: |
RN19A_HUMAN |
| Immunogen Region: |
639-838 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 639-838 of human RNF19A (NP_056250.3). |
| Immunogen Sequence: |
GSATRSHAGGSSSGLPEGKS SATKWSKEATAGKKSKSGKL RKKGNMKINETREDMDAQLL EQQSTNSSEFEAPSLSDSMP SVADSHSSHFSEFSCSDLES MKTSCSHGSSDYHTRFATVN ILPEVENDRLENSPHQCSIS VVTQTASCSEVSQLNHIAEE HGNNGIKPNVDLYFGDALKE TNNNHSHQTMELKVAIQTEI |
| Tissue Specificity | Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf19aDouble Ring-Finger ProteinDorfinRing Finger Protein 19aP38 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomePresent In The Hyaline Inclusion Bodies Specifically Found In Motor Neurons From Amyotrophic Lateral Sclerosis PatientsPresent In The Lewy Bodies Specifically Found In Neurons From Parkinson Disease Patients |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf19a antibodyAnti-Double Ring-Finger Protein antibodyAnti-Dorfin antibodyAnti-Ring Finger Protein 19a antibodyAnti-P38 antibodyAnti-RNF19A antibodyAnti-RNF19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
