| Tissue Specificity | Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf19aDouble Ring-Finger ProteinDorfinRing Finger Protein 19aP38 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomePresent In The Hyaline Inclusion Bodies Specifically Found In Motor Neurons From Amyotrophic Lateral Sclerosis PatientsPresent In The Lewy Bodies Specifically Found In Neurons From Parkinson Disease Patients |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf19a antibodyAnti-Double Ring-Finger Protein antibodyAnti-Dorfin antibodyAnti-Ring Finger Protein 19a antibodyAnti-P38 antibodyAnti-RNF19A antibodyAnti-RNF19 antibody |
Information sourced from Uniprot.org
