| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death.But, it is not an anti-apoptotic protein per se. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf144bIbr Domain-Containing Protein 2Ring Finger Protein 144bP53-Inducible Ring Finger Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmMostly CytosololicAccumulates In Submitochondrial Domains Specifically Upon Apoptosis InductionIn Synchrony With Bax Activation |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf144b antibodyAnti-Ibr Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 144b antibodyAnti-P53-Inducible Ring Finger Protein antibodyAnti-RNF144B antibodyAnti-IBRDC2 antibodyAnti-P53RFP antibody |
Information sourced from Uniprot.org
