| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF112 (200-500) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF112 |
| Gene ID: |
7732 |
| Uniprot ID: |
RN112_HUMAN |
| Immunogen Region: |
200-500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human RNF112 (NP_009079.2). |
| Immunogen Sequence: |
EGGRPRGGEASLQGCRWGAN GLARGIWMWSHPFLLGKEGK KVAVFLVDTGDAMSPELSRE TRIKLCALTTMLSSYQILST SQELKDTDLDYLEMFVHVAE VMGKHYGMVPIQHLDLLVRD SSHPNKAGQGHVGNIFQRLS GRYPKVQELLQGKRARCCLL PAPGRRRMNQGHASPGDTDD DFRHLLGAYVSDVLSAAPQH AKSRCQGYWNEGRAVARGDR RLLTGQQLAQEIKNLSGWM |
| Tissue Specificity | Predominantly expressed in brain. Decreased expression in glioma brain tumors as compared to normal brains (at protein level). |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission.its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. |
| Protein Name | Ring Finger Protein 112Brain Finger ProteinZinc Finger Protein 179 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinPeripheral Membrane ProteinCytoplasmNucleusNuclear BodyNucleoplasmEndosomeCytoplasmic VesicleSecretory VesicleSynaptic VesiclePostsynaptic DensityPerikaryonCell ProjectionNeuron ProjectionPredominantly In The NucleusBut Some Amounts Were Also Found In The CytoplasmOxidative Stress Stimulates Its Shuttling From The Cytoplasm Into The NucleusRecruited To Nuclear Bodies Via Its Interaction With Zbtb16Localizes To The Cell Soma And Neuritis And Only Slightly To The Nucleus In The Neurons Of Most Brain Areas |
| Alternative Antibody Names | Anti-Ring Finger Protein 112 antibodyAnti-Brain Finger Protein antibodyAnti-Zinc Finger Protein 179 antibodyAnti-RNF112 antibodyAnti-BFP antibodyAnti-ZNF179 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
