| Tissue Specificity | Expressed in all tissues examined with high levels in brain, placenta and pancreas. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins. |
| Function | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. |
| Protein Name | Ras And Rab Interactor 1Ras Inhibitor Jc99Ras Interaction/Interference Protein 1 |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmMembraneCytoskeletonSome Amount Is Membrane-Associated |
| Alternative Antibody Names | Anti-Ras And Rab Interactor 1 antibodyAnti-Ras Inhibitor Jc99 antibodyAnti-Ras Interaction/Interference Protein 1 antibodyAnti-RIN1 antibody |
Information sourced from Uniprot.org
