| Tissue Specificity | Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain. |
| Function | Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. |
| Protein Name | Protein Ric-3Resistant To Inhibitor Of Cholinesterase 3 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinIsoform 2: Endoplasmic Reticulum MembraneGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Protein Ric-3 antibodyAnti-Resistant To Inhibitor Of Cholinesterase 3 antibodyAnti-RIC3 antibodyAnti-UNQ720 antibodyAnti-PRO1385 antibody |
Information sourced from Uniprot.org
