| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RGS8 |
| Gene ID: | 85397 |
| Uniprot ID: | RGS8_HUMAN |
| Immunogen Region: | 1-180 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human RGS8 (NP_001095920.1). |
| Immunogen Sequence: | MAALLMPRRNKGMRTRLGCL SHKSDSCSDFTAILPDKPNR ALKRLSTEEATRWADSFDVL LSHKYGVAAFRAFLKTEFSE ENLEFWLACEEFKKTRSTAK LVSKAHRIFEEFVDVQAPRE VNIDFQTREATRKNLQEPSL TCFDQAQGKVHSLMEKDSYP RFLRSKMYLDLLSQSQRRLS |
| Function | Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling. |
| Protein Name | Regulator Of G-Protein Signaling 8 Rgs8 |
| Database Links | Reactome: R-HSA-418594 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Membrane Perikaryon Cell Projection Dendrite Nucleus Detected In Purkinje Cell Soma And Dendrites Associated With Purkinje Cell Membranes Not Detected In Purkinje Cell Nuclei Detected In The Nucleus After Heterologous Expression Recruited To The Cell Membrane In The Presence Of Gnao1 |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 8 antibody Anti-Rgs8 antibody Anti-RGS8 antibody |
Information sourced from Uniprot.org