| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-REG3G (27-174) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Reg3g |
| Gene ID: |
19695 |
| Uniprot ID: |
REG3G_MOUSE |
| Immunogen Region: |
27-174 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-174 of mouse REG3G (NP_035390.1). |
| Immunogen Sequence: |
EVAKKDAPSSRSSCPKGSRA YGSYCYALFSVSKNWYDADM ACQKRPSGHLVSVLSGAEAS FLSSMIKSSGNSGQYVWIGL HDPTLGYEPNRGGWEWSNAD VMNYINWETNPSSSSGNHCG TLSRASGFLKWRENYCNLEL PYVCKFKA |
| Tissue Specificity | Predominantly expressed in the small intestine, including Paneth cells (at protein level). Hardly detectable in the colon (at protein level). Highly expressed in the lung epithelium during methicillin-resistant S.aureus infection and allergic airway inflammation (at protein level). Skin injury increases its epidermal expression. Also expressed in the pancreas. Expressed by nocireceptors. |
| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. Regenerating islet-derived protein 3-gamma 16.5 kDa form: Has bacteriostatic activity. Regenerating islet-derived protein 3-gamma 15 kDa form: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. |
| Protein Name | Regenerating Islet-Derived Protein 3-GammaReg-3-GammaPancreatitis-Associated Protein 3Regenerating Islet-Derived Protein Iii-GammaReg Iii-Gamma Cleaved Into - Regenerating Islet-Derived Protein 3-Gamma 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Gamma 15 Kda Form |
| Database Links | Reactome: R-MMU-6803157 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Regenerating Islet-Derived Protein 3-Gamma antibodyAnti-Reg-3-Gamma antibodyAnti-Pancreatitis-Associated Protein 3 antibodyAnti-Regenerating Islet-Derived Protein Iii-Gamma antibodyAnti-Reg Iii-Gamma Cleaved Into - Regenerating Islet-Derived Protein 3-Gamma 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Gamma 15 Kda Form antibodyAnti-Reg3g antibodyAnti-Pap3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
