![Anti-Recombinant-Tyrosine Hydroxylase antibody [SR0614] (STJA0010614)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180509/404295/STJA0010614_3__00317.1738951432.jpg?c=1 "Anti-Recombinant-Tyrosine Hydroxylase antibody [SR0614] (STJA0010614)")
![Anti-Recombinant-Tyrosine Hydroxylase antibody [SR0614] (STJA0010614)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180509/404295/STJA0010614_3__00317.1738951432.jpg?c=1 "Anti-Recombinant-Tyrosine Hydroxylase antibody [SR0614] (STJA0010614)")
| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Tyrosine Hydroxylase is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SR0614 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | IHC/IF (M, R, Mk) 1:500-1:1000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Th |
| Gene ID: | 21823 |
| Uniprot ID: | TY3H_MOUSE |
| Immunogen: | Recombinant protein corresponding to Mouse Tyrosine Hydroxylase |
| Post Translational Modifications | Phosphorylated on Ser-19, Ser-31 and Ser-40 by several protein kinases with different site specificities. Phosphorylation at Ser-31 and Ser-40 leads to an increase of TH activity. Phosphorylation at Ser-40 activates the enzyme and also counteracts the feedback inhibition of TH by catecholamines. Phosphorylation of Ser-19 and Ser-31 triggers the proteasomal degradation of TH through the ubiquitin-proteasome pathway. Phosphorylation at Ser-31 facilitates transport of TH from the soma to the nerve terminals via the microtubule network. Phosphorylation at Ser-19 induces the high-affinity binding to the 14-3-3 protein YWHAG.this interaction may influence the phosphorylation and dephosphorylation of other sites. Ser-19 increases the phosphorylation at Ser-40 in a hierarchical manner, leading to increased activity. |
| Function | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa. In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development. |
| Protein Name | Tyrosine 3-Monooxygenase Tyrosine 3-Hydroxylase Th |
| Database Links | Reactome: R-MMU-209905 |
| Cellular Localisation | Cytoplasm Perinuclear Region Nucleus Cell Projection Axon Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle When Phosphorylated At Ser-19 Shows A Nuclear Distribution And When Phosphorylated At Ser-31 As Well As At Ser-40 Shows A Cytosolic Distribution Expressed In Dopaminergic Axons And Axon Terminals |
| Alternative Antibody Names | Anti-Tyrosine 3-Monooxygenase antibody Anti-Tyrosine 3-Hydroxylase antibody Anti-Th antibody Anti-Th antibody |
Information sourced from Uniprot.org