| Post Translational Modifications | Constitutively phosphorylated by PKC on serine/threonine in A431 cells. |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Protein Name | Tripartite Motif-Containing Protein 29Ataxia Telangiectasia Group D-Associated Protein |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmLysosomeColocalizes With Intermediate Filaments |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 29 antibodyAnti-Ataxia Telangiectasia Group D-Associated Protein antibodyAnti-TRIM29 antibodyAnti-ATDC antibody |
Information sourced from Uniprot.org
