| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing. |
| Protein Name | Syntaxin-4Renal Carcinoma Antigen Ny-Ren-31 |
| Database Links | Reactome: R-HSA-114516Reactome: R-HSA-1236974Reactome: R-HSA-1445148Reactome: R-HSA-199992Reactome: R-HSA-449836 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iv Membrane ProteinCell ProjectionNeuron ProjectionStereociliumLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Syntaxin-4 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-31 antibodyAnti-STX4 antibodyAnti-STX4A antibody |
Information sourced from Uniprot.org
