| Function | Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine. Mediates the bidirectional transport of polyamine agmatine. Also transports guanidine. May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling. |
| Protein Name | Solute Carrier Family 22 Member 3Extraneuronal Monoamine TransporterEmtOrganic Cation Transporter 3Oct3 |
| Database Links | Reactome: R-HSA-2161517Reactome: R-HSA-549127 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell MembraneMitochondrion MembraneEndomembrane SystemNucleus MembraneNucleus Outer MembraneLocalized To The Apical/Brush Border Membrane Of EnterocytesLocalized To The Luminal/Apical Membrane Of Ciliated Epithelial Cells In BronchiLocalized To The Basolateral Membrane Of Intermediate Cells In BronchiLocalized To The Entire Plasma Membrane Of Basal Cells In Bronchi |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 3 antibodyAnti-Extraneuronal Monoamine Transporter antibodyAnti-Emt antibodyAnti-Organic Cation Transporter 3 antibodyAnti-Oct3 antibodyAnti-SLC22A3 antibodyAnti-EMTH antibodyAnti-OCT3 antibody |
Information sourced from Uniprot.org
