Anti-Recombinant-MYO7A antibody [RM2E28] (STJA0025398)

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STJA0025398
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: FC/IF/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Unconventional Myosin-Viia is suitable for use in Flow Cytometry, Immunofluorescence and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2E28
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IF: 1:50-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: MYO7A
Gene ID: 4647
Uniprot ID: MYO7A_HUMAN
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Protein Name Unconventional Myosin-Viia
Database Links Reactome: R-HSA-2453902
Reactome: R-HSA-9662360
Reactome: R-HSA-9662361
Cellular Localisation Cytoplasm
Cell Cortex
Cytoskeleton
Synapse
In The Photoreceptor Cells
Mainly Localized In The Inner And Base Of Outer Segments As Well As In The Synaptic Ending Region
In Retinal Pigment Epithelial Cells Colocalizes With A Subset Of Melanosomes
Displays Predominant Localization To Stress Fiber-Like Structures And Some Localization To Cytoplasmic Puncta
Detected At The Tip Of Cochlear Hair Cell Stereocilia
The Complex Formed By Myo7a
Ush1c And Ush1g Colocalizes With F-Actin
Alternative Antibody Names Anti-Unconventional Myosin-Viia antibody
Anti-MYO7A antibody
Anti-USH1B antibody

Information sourced from Uniprot.org

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