| Host: | Rabbit |
| Applications: | IF/IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Insulin Receptor Substrate 1 is suitable for use in Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1V10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IF: 1:50-1:200 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | IRS1 |
| Gene ID: | 3667 |
| Uniprot ID: | IRS1_HUMAN |
| Function | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2. Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade. Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation. |
| Protein Name | Insulin Receptor Substrate 1Irs-1 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-112399Reactome: R-HSA-112412Reactome: R-HSA-1257604Reactome: R-HSA-1266695Reactome: R-HSA-198203Reactome: R-HSA-201556Reactome: R-HSA-2219530Reactome: R-HSA-2428928Reactome: R-HSA-2586552Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-74713Reactome: R-HSA-74749Reactome: R-HSA-9603381Reactome: R-HSA-9725370Reactome: R-HSA-982772Reactome: R-HSA-9842663 |
| Cellular Localisation | CytoplasmNucleusNuclear Or Cytoplasmic Localization Of Irs1 Correlates With The Transition From Proliferation To Chondrogenic Differentiation |
| Alternative Antibody Names | Anti-Insulin Receptor Substrate 1 antibodyAnti-Irs-1 antibodyAnti-IRS1 antibody |
Information sourced from Uniprot.org
