Host: | Rabbit |
Applications: | WB/IHC-P/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:100 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | RDH5 |
Gene ID: | 5959 |
Uniprot ID: | RDH5_HUMAN |
Immunogen Region: | 24-318 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-318 of human RDH5 (NP_002896.2). |
Immunogen Sequence: | LPASNAFVFITGCDSGFGRL LALQLDQRGFRVLASCLTPS GAEDLQRVASSRLHTTLLDI TDPQSVQQAAKWVEMHVKEA GLFGLVNNAGVAGIIGPTPW LTRDDFQRVLNVNTMGPIGV TLALLPLLQQARGRVINITS VLGRLAANGGGYCVSKFGLE AFSDSLRRDVAHFGIRVSIV EPGFFRTPVTNLESLEKTLQ ACWARLPPATQAHYGGAFLT KYLKMQQRIMNLICDPDLT |
Tissue Specificity | Widely expressed. In the eye, abundant in the retinal pigment epithelium. |
Function | Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates. |
Protein Name | Retinol Dehydrogenase 5 11-Cis Retinol Dehydrogenase 11-Cis Rdh 11-Cis Rodh 9-Cis Retinol Dehydrogenase 9crdh Short Chain Dehydrogenase/Reductase Family 9c Member 5 |
Database Links | Reactome: R-HSA-2453864 Reactome: R-HSA-2453902 Reactome: R-HSA-5365859 |
Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Lumenal Side |
Alternative Antibody Names | Anti-Retinol Dehydrogenase 5 antibody Anti-11-Cis Retinol Dehydrogenase antibody Anti-11-Cis Rdh antibody Anti-11-Cis Rodh antibody Anti-9-Cis Retinol Dehydrogenase antibody Anti-9crdh antibody Anti-Short Chain Dehydrogenase/Reductase Family 9c Member 5 antibody Anti-RDH5 antibody Anti-HSD17B9 antibody Anti-RDH1 antibody Anti-SDR9C5 antibody |
Information sourced from Uniprot.org