| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-RASSF7/HRAS1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 37kDa band observed in lysates of cell line Jurkat (calculated MW of 39.9kDa according to NP_003466.1). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | RASSF7 |
| Gene ID: | 8045 |
| Uniprot ID: | RASF7_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_003466.1 |
| Immunogen Sequence: | CTDLRGLELRVQRN |
| Function | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
| Protein Name | Ras Association Domain-Containing Protein 7Hras1-Related Cluster Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Gamma-Tubulin |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 7 antibodyAnti-Hras1-Related Cluster Protein 1 antibodyAnti-RASSF7 antibodyAnti-C11orf13 antibodyAnti-HRC1 antibody |
Information sourced from Uniprot.org