| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RANBP10 |
| Gene ID: |
57610 |
| Uniprot ID: |
RBP10_HUMAN |
| Immunogen Region: |
362-497 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1). |
| Immunogen Sequence: |
YPGSPSLSPRHGPSSSHMHN TGADSPSCSNGVASTKSKQN HSKYPAPSSSSSSSSSSSSS SPSSVNYSESNSTDSTKSQH HSSTSNQETSDSEMEMEAEH YPNGVLGSMSTRIVNGAYKH EDLQTDESSMDDRHPR |
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle. |
| Function | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function. |
| Protein Name | Ran-Binding Protein 10Ranbp10 |
| Database Links | Reactome: R-HSA-8851805 |
| Cellular Localisation | CytoplasmCytosolNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Ran-Binding Protein 10 antibodyAnti-Ranbp10 antibodyAnti-RANBP10 antibodyAnti-KIAA1464 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
