| Post Translational Modifications | Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR). Phosphorylated. Phosphorylation at Ser-572 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA. |
| Function | Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA. |
| Protein Name | Dna Repair And Recombination Protein Rad54-LikeRad54 HomologHhr54Hrad54 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna Repair And Recombination Protein Rad54-Like antibodyAnti-Rad54 Homolog antibodyAnti-Hhr54 antibodyAnti-Hrad54 antibodyAnti-RAD54L antibodyAnti-RAD54A antibody |
Information sourced from Uniprot.org
