| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PURB |
| Gene ID: |
5814 |
| Uniprot ID: |
PURB_HUMAN |
| Immunogen Region: |
213-312 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 213-312 of human PURB (NP_150093.1). |
| Immunogen Sequence: |
GGLYGELPEGTSITVDSKRF FFDVGCNKYGVFLRVSEVKP SYRNAITVPFKAWGKFGGAF CRYADEMKEIQERQRDKLYE RRGGGSGGGEESEGEEVDED |
| Tissue Specificity | Expressed in myocardium of heart failure patients. |
| Function | Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes. Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. |
| Protein Name | Transcriptional Regulator Protein Pur-BetaPurine-Rich Element-Binding Protein B |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Regulator Protein Pur-Beta antibodyAnti-Purine-Rich Element-Binding Protein B antibodyAnti-PURB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
