| Background | PU.1 is a transcription factor that has been shown to be important for normal B-cell development. PU.1 belongs to the ETS family of transcription factors. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the prepro stage. Very little is known about PU.1 function in later stages of B-cell development. PU.1 does not seem to play a role in the end-stage of B-cell development and is not expressed in plasma cells. PU.1 exerts an important role in the regulation of the expression of crucial B-cell proteins, such as immunoglobulin (Ig) genes, and CD20 and its putative binding sites were also identified in the promoters of CD79, CD10, and CD22. PU.1 binds to the 3 enhancer region of both the Ig kappa and lambda light chain genes and it also regulates the immunoglobulin heavy chain genes through the intron enhancer region. |
Information sourced from Uniprot.org
![Anti-PU.1 antibody [EPR3158Y] (STJ16100421)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149138/346759/STJ16100421_1__87929.1681998856.jpg?c=1 "Anti-PU.1 antibody [EPR3158Y] (STJ16100421)")
![Anti-PU.1 antibody [EPR3158Y] (STJ16100421)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149138/346759/STJ16100421_1__87929.1681998856.jpg?c=1 "Anti-PU.1 antibody [EPR3158Y] (STJ16100421)")
