| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTPRS (1100-1280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPRS |
| Gene ID: |
5802 |
| Uniprot ID: |
PTPRS_HUMAN |
| Immunogen Region: |
1100-1280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1280 of human PTPRS (NP_002841.3). |
| Immunogen Sequence: |
TNRGSSLGGLQQTVTAWTAF NLLNGKPSVAPKPDADGFIM VYLPDGQSPVPVQSYFIVMV PLRKSRGGQFLTPLGSPEDM DLEELIQDISRLQRRSLRHS RQLEVPRPYIAARFSVLPPT FHPGDQKQYGGFDNRGLEPG HRYVLFVLAVLQKSEPTFAA SPFSDPFQLDNPDPQPIVDG E |
| Tissue Specificity | Detected in peripheral blood plasmacytoid dendritic cells (at protein level). Detected in all tissues tested except for placenta and liver. Detected in peripheral blood plasmacytoid dendritic cells. |
| Post Translational Modifications | A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization. |
| Function | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase SR-Ptp-SReceptor-Type Tyrosine-Protein Phosphatase SigmaR-Ptp-Sigma |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-388844Reactome: R-HSA-8849932Reactome: R-HSA-9034015 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonPerikaryonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSynapseSynaptosomePostsynaptic DensityNeuron ProjectionGrowth ConeIs Rapidly Internalized When Dendritic Cells Are Stimulated With The Tlr9 Ligand Cytidine-Phosphate-Guanosine (Cpg)Detected In A Punctate Pattern Along Neurites And Axon Growth Cones |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase S antibodyAnti-R-Ptp-S antibodyAnti-Receptor-Type Tyrosine-Protein Phosphatase Sigma antibodyAnti-R-Ptp-Sigma antibodyAnti-PTPRS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
