| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRLR |
| Gene ID: | 5618 |
| Uniprot ID: | PRLR_HUMAN |
| Immunogen Region: | 25-234 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human Prolactin Receptor (NP_000940.1). |
| Immunogen Sequence: | QLPPGKPEIFKCRSPNKETF TCWWRPGTDGGLPTNYSLTY HREGETLMHECPDYITGGPN SCHFGKQYTSMWRTYIMMVN ATNQMGSSFSDELYVDVTYI VQPDPPLELAVEVKQPEDRK PYLWIKWSPPTLIDLKTGWF TLLYEIRLKPEKAAEWEIHF AGQQTEFKILSLHPGQKYLV QVRCKPDHGYWSAWSPATFI QIPSDFTMND |
| Tissue Specificity | Expressed in breast, placenta, kidney, liver and pancreas. |
| Function | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
| Protein Name | Prolactin ReceptorPrl-R |
| Database Links | Reactome: R-HSA-1170546Reactome: R-HSA-982772 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 7: Secreted |
| Alternative Antibody Names | Anti-Prolactin Receptor antibodyAnti-Prl-R antibodyAnti-PRLR antibody |
Information sourced from Uniprot.org