| Tissue Specificity | Highly expressed in the intestinal epithelial cells (at protein level). Abundantly expressed in the epithelial cells of the liver, kidney and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level). |
| Function | Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion. Protects the gastrointestinal epithelium from irradiation-induced apoptosis. May play an important role in maintaining normal growth homeostasis in epithelial cells. Involved in p53/TP53-dependent cell survival after DNA damage. May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas. |
| Protein Name | Proline-Rich Acidic Protein 1Epididymis Tissue Protein Li 178Uterine-Specific Proline-Rich Acidic Protein |
| Cellular Localisation | SecretedEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Proline-Rich Acidic Protein 1 antibodyAnti-Epididymis Tissue Protein Li 178 antibodyAnti-Uterine-Specific Proline-Rich Acidic Protein antibodyAnti-PRAP1 antibodyAnti-UPA antibodyAnti-UNQ608 antibodyAnti-PRO1195 antibody |
Information sourced from Uniprot.org
