| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pqbp1 (170-263) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Pqbp1 |
| Gene ID: |
54633 |
| Uniprot ID: |
PQBP1_MOUSE |
| Immunogen Region: |
170-263 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-263 of mouse Pqbp1 (NP_062351.2). |
| Immunogen Sequence: |
EGKDRRHHRREELAPYPKNK KATSRKDEELDPMDPSSYSD APRGTWSTGLPKRNEAKTGA DTTAAGPLFQQRPYPSPGAV LRANAEASRTKQQD |
| Tissue Specificity | Detected in brain cortex and hippocampus neurons (at protein level). Expressed in brain with high level in cerebellar cortex, hippocampus and olfactory bulb. |
| Function | Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. |
| Protein Name | Polyglutamine-Binding Protein 1Pqbp-138 Kda Nuclear Protein Containing A Ww DomainNpw38Polyglutamine Tract-Binding Protein 1 |
| Database Links | Reactome: R-MMU-72163 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmic GranuleColocalizes With Srsf2 In Nuclear SpecklesColocalized With Pou3f2Colocalized With Atxn1 In Nuclear Inclusion BodiesLocalizes To Cytoplasmic Stress Granules |
| Alternative Antibody Names | Anti-Polyglutamine-Binding Protein 1 antibodyAnti-Pqbp-1 antibodyAnti-38 Kda Nuclear Protein Containing A Ww Domain antibodyAnti-Npw38 antibodyAnti-Polyglutamine Tract-Binding Protein 1 antibodyAnti-Pqbp1 antibodyAnti-Npw38 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
