| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/threonine-protein phosphatase 6 catalytic subunit is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP6C |
| Gene ID: |
5537 |
| Uniprot ID: |
PPP6_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PPP6C at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PPP6C |
| Function | Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it. |
| Protein Name | Serine/Threonine-Protein Phosphatase 6 Catalytic SubunitPp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-204005 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit antibodyAnti-Pp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed antibodyAnti-PPP6C antibodyAnti-PPP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
