Western blot analysis of lysates from K562 and COS7 cells, using PPP4R2 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-PPP4R2 antibody (171-220 aa) (STJ95199)

SKU:
STJ95199
£48.00 - £252.00
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Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Serine/threonine-protein phosphatase 4 regulatory subunit 2 (171-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PPP4R2
Gene ID: 151987
Uniprot ID: PP4R2_HUMAN
Immunogen Region: 171-220 aa
Specificity: PP4R2 Polyclonal Antibody detects endogenous levels of PP4R2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human PPP4R2 at the amino acid range 171-220
Function Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Protein Name Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 2
Database Links Reactome: R-HSA-5693607
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Nucleus
Ionizing Radiation Induces Relocalization To Nuclear Foci And Colocalization With Rpa2
Alternative Antibody Names Anti-Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 2 antibody
Anti-PPP4R2 antibody
Anti-SBBI57 antibody

Information sourced from Uniprot.org

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