| Tissue Specificity | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. |
| Function | Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity. |
| Protein Name | Prepronociceptin Cleaved Into - Nocistatin - NociceptinOrphanin FqPpnoc - Orphanin Fq2 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Prepronociceptin Cleaved Into - Nocistatin - Nociceptin antibodyAnti-Orphanin Fq antibodyAnti-Ppnoc - Orphanin Fq2 antibodyAnti-PNOC antibodyAnti-OFQ antibody |
Information sourced from Uniprot.org
