| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PMF1 |
| Gene ID: | 100527963/11243 |
| Uniprot ID: | PMF1_HUMAN |
| Immunogen Region: | 1-205 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human PMF1 (NP_009152.2). |
| Immunogen Sequence: | MAEASSANLGSGCEEKRHEG SSSESVPPGTTISRVKLLDT MVDTFLQKLVAAGSYQRFTD CYKCFYQLQPAMTQQIYDKF IAQLQTSIREEISDIKEEGN LEAVLNALDKIVEEGKVRKE PAWRPSGIPEKDLHSVMAPY FLQQRDTLRRHVQKQEAENQ QLADAVLAGRRQVEELQLQV QAQQQAWQALHREQRELVAV LREPE |
| Tissue Specificity | Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver. |
| Function | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. |
| Protein Name | Polyamine-Modulated Factor 1Pmf-1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreAssociated With The Kinetochore |
| Alternative Antibody Names | Anti-Polyamine-Modulated Factor 1 antibodyAnti-Pmf-1 antibodyAnti-PMF1 antibody |
Information sourced from Uniprot.org