| Tissue Specificity | Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. |
| Function | Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. |
| Protein Name | Plexin-B3 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinColocalizes With Rit2/Rin At The Plasma Membrane |
| Alternative Antibody Names | Anti-Plexin-B3 antibodyAnti-PLXNB3 antibodyAnti-KIAA1206 antibodyAnti-PLXN6 antibody |
Information sourced from Uniprot.org
