| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLXNB3 |
| Gene ID: | 5365 |
| Uniprot ID: | PLXB3_HUMAN |
| Immunogen Region: | 1050-1250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human PLXNB3 (NP_001156729.1). |
| Immunogen Sequence: | RGGGRLIRVRGTGLDVVQRP LLSVWLEADAEVQASRAQPQ DPQPRRSCGAPAADPQACIQ LGGGLLQCSTVCSVNSSSLL LCRSPAVPDRAHPQRVFFTL DNVQVDFASASGGQGFLYQP NPRLAPLSREGPARPYRLKP GHVLDVEGEGLNLGISKEEV RVHIGRGECLVKTLTRTHLY CEPPAHAPQPANGSGLPQFV V |
| Tissue Specificity | Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. |
| Function | Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. |
| Protein Name | Plexin-B3 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Colocalizes With Rit2/Rin At The Plasma Membrane |
| Alternative Antibody Names | Anti-Plexin-B3 antibody Anti-PLXNB3 antibody Anti-KIAA1206 antibody Anti-PLXN6 antibody |
Information sourced from Uniprot.org