| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLXNA4 |
| Gene ID: | 91584 |
| Uniprot ID: | PLXA4_HUMAN |
| Immunogen Region: | 24-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human PLXNA4 (NP_861440.2). |
| Immunogen Sequence: | TLLTRQPAPLSQKQRSFVTF RGEPAEGFNHLVVDERTGHI YLGAVNRIYKLSSDLKVLVT HETGPDEDNPKCYPPRIVQT CNEPLTTTNNVNKMLLIDYK ENRLIACGSLYQGICKLLRL EDLFKLGEPYHKKEHYLSGV NESGSVFGVIVSYSNLDDKL FIATAVDGKPEYFPTISSRK LTKNSEADGMFAYVFHD |
| Function | Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| Protein Name | Plexin-A4 |
| Database Links | Reactome: R-HSA-399954Reactome: R-HSA-399955Reactome: R-HSA-399956Reactome: R-HSA-416700Reactome: R-HSA-9615017 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Plexin-A4 antibodyAnti-PLXNA4 antibodyAnti-KIAA1550 antibodyAnti-PLXNA4A antibodyAnti-PLXNA4B antibodyAnti-UNQ2820 antibodyAnti-PRO34003 antibody |
Information sourced from Uniprot.org