| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLXNA2 (300-560) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLXNA2 |
| Gene ID: |
5362 |
| Uniprot ID: |
PLXA2_HUMAN |
| Immunogen Region: |
300-560 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-560 of human PLXNA2 (NP_079455.3). |
| Immunogen Sequence: |
CTRAGVEYRLLQAAYLAKPG DSLAQAFNITSQDDVLFAIF SKGQKQYHHPPDDSALCAFP IRAINLQIKERLQSCYQGEG NLELNWLLGKDVQCTKAPVP IDDNFCGLDINQPLGGSTPV EGLTLYTTSRDRMTSVASYV YNGYSVVFVGTKSGKLKKIR ADGPPHGGVQYEMVSVLKDG SPILRDMAFSIDQRYLYVMS ERQVTRVPVESCEQYTTCGE CLSSGDPHCGWCALHNMCS |
| Tissue Specificity | Detected in fetal brain. |
| Function | Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| Protein Name | Plexin-A2Semaphorin Receptor Oct |
| Database Links | Reactome: R-HSA-399954Reactome: R-HSA-399955Reactome: R-HSA-399956Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Plexin-A2 antibodyAnti-Semaphorin Receptor Oct antibodyAnti-PLXNA2 antibodyAnti-KIAA0463 antibodyAnti-OCT antibodyAnti-PLXN2 antibodyAnti-UNQ209 antibodyAnti-PRO235 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
