| Tissue Specificity | Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat. |
| Post Translational Modifications | C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage. |
| Function | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. |
| Protein Name | Pleckstrin Homology Domain-Containing Family O Member 1Ph Domain-Containing Family O Member 1C-Jun-Binding ProteinJbpCasein Kinase 2-Interacting Protein 1Ck2-Interacting Protein 1Ckip-1Osteoclast Maturation-Associated Gene 120 Protein |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinNucleusCytoplasmPredominantly Localized To The Plasma Membrane Through The Binding To Phosphatidylinositol 3-PhosphateIn C2c12 CellsWith The Absence Of Growth FactorIt Is Found In The NucleusIt Rapidly Translocates To The Plasma Membrane After Insulin StimulationIn Response To TnfIt Translocates From The Plasma Membrane To The Cytoplasm And Then To The Nucleus Accompanied By Cleavage By Caspase-3HoweverThe Subcellular Location Is Highly Dependent Of The Cell TypeAnd This Explains Why It Is Found Exclusively At The Plasma MembraneIn Some Type Of Cells (Probable) |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family O Member 1 antibodyAnti-Ph Domain-Containing Family O Member 1 antibodyAnti-C-Jun-Binding Protein antibodyAnti-Jbp antibodyAnti-Casein Kinase 2-Interacting Protein 1 antibodyAnti-Ck2-Interacting Protein 1 antibodyAnti-Ckip-1 antibodyAnti-Osteoclast Maturation-Associated Gene 120 Protein antibodyAnti-PLEKHO1 antibodyAnti-CKIP1 antibodyAnti-OC120 antibodyAnti-HQ0024c antibody |
Information sourced from Uniprot.org
