![Anti-PLAP antibody [NB-10] (STJ16100416)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149133/346754/STJ16100416_1__78027.1681998850.jpg?c=1 "Anti-PLAP antibody [NB-10] (STJ16100416)")
![Anti-PLAP antibody [NB-10] (STJ16100416)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149133/346754/STJ16100416_1__78027.1681998850.jpg?c=1 "Anti-PLAP antibody [NB-10] (STJ16100416)")
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-PLAP is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | NB-10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Dilution Range: | IHC 1:50 – 1:200 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | PLAA |
| Gene ID: | 9373 |
| Uniprot ID: | PLAP_HUMAN |
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Protein Name | Phospholipase A-2-Activating Protein Pla2p Plap |
| Cellular Localisation | Nucleus Cytoplasm Synapse Recruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Phospholipase A-2-Activating Protein antibody Anti-Pla2p antibody Anti-Plap antibody Anti-PLAA antibody Anti-PLAP antibody |
Information sourced from Uniprot.org