| Tissue Specificity | Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. |
| Post Translational Modifications | Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization. Ubiquitinated by ITCH.this does not lead to proteasomal degradation. |
| Function | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). |
| Protein Name | Phosphatidylinositol 4-Kinase Type 2-AlphaPhosphatidylinositol 4-Kinase Type Ii-Alpha |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660514Reactome: R-HSA-1660516 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneLipid-AnchorMembrane RaftCell ProjectionDendritePresynaptic Cell MembraneSynapseSynaptosomeMitochondrionEndosomeEndosome MembraneCytoplasmic VesicleMembraneCell MembranePerikaryonNeuron ProjectionFound In Subdomains Of The Plasma Membrane Termed Non-Caveolar Membrane RaftsTransported From Neuronal Cell Body To Neuron Projections And Neurite Tips In A Bloc-1- And Ap-3-Complexes-Dependent Manner |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Kinase Type 2-Alpha antibodyAnti-Phosphatidylinositol 4-Kinase Type Ii-Alpha antibodyAnti-PI4K2A antibody |
Information sourced from Uniprot.org
