Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Phospho-PNKP-Ser114/Thr118 antibody (STJ196388)

SKU:
STJ196388
$64.80 - $340.20
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Bifunctional polynucleotide phosphatase/kinase-Ser114/Thr118 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PNKP
Gene ID: 11284
Uniprot ID: PNKP_HUMAN
Specificity: This antibody detects endogenous levels of Human PNK1 (phospho-Ser114 or Thr118)
Immunogen: Synthesized phosho peptide around human PNK1 (Ser114 and Thr118)
Function Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Protein Name Bifunctional Polynucleotide Phosphatase/Kinase
Dna 5'-Kinase/3'-Phosphatase
Polynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase
2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase
Database Links Reactome: R-HSA-5649702
Cellular Localisation Nucleus
Chromosome
Localizes To Site Of Double-Strand Breaks
Alternative Antibody Names Anti-Bifunctional Polynucleotide Phosphatase/Kinase antibody
Anti-Dna 5'-Kinase/3'-Phosphatase antibody
Anti-Polynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase antibody
Anti-2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase antibody
Anti-PNKP antibody

Information sourced from Uniprot.org

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