| Function | Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts. |
| Protein Name | Pleckstrin Homology Domain-Containing Family G Member 5Ph Domain-Containing Family G Member 5Guanine Nucleotide Exchange Factor 720Gef720 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell MembraneCell JunctionCell ProjectionLamellipodiumPredominantly CytoplasmicHowever When Endothelial Cells Are Stimulated With Lysophosphatidic AcidPlekhg5 Is Found In Perinuclear Regions And At The Cell MembraneLocalizes At Cell-Cell Junctions In Quiescent Endothelial CellsAnd Relocalizes To Cytoplasmic Vesicle And The Leading Edge Of Lamellipodia In Migrating Endothelial Cells |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family G Member 5 antibodyAnti-Ph Domain-Containing Family G Member 5 antibodyAnti-Guanine Nucleotide Exchange Factor 720 antibodyAnti-Gef720 antibodyAnti-PLEKHG5 antibodyAnti-KIAA0720 antibody |
Information sourced from Uniprot.org
