| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Nuclear receptor coactivator 1-Thr1179 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCOA1 |
| Gene ID: | 8648 |
| Uniprot ID: | NCOA1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Human, Mouse SRC-1 (Phospho Thr1179) |
| Immunogen: | Synthesized peptide derived from human SRC-1 (Phospho Thr1179) |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Sumoylated.sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein. Ubiquitinated.leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4.the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. |
| Protein Name | Nuclear Receptor Coactivator 1 Ncoa-1 Class E Basic Helix-Loop-Helix Protein 74 Bhlhe74 Protein Hin-2 Rip160 Renal Carcinoma Antigen Ny-Ren-52 Steroid Receptor Coactivator 1 Src-1 |
| Database Links | Reactome: R-HSA-1368082 Reactome: R-HSA-1368108 Reactome: R-HSA-159418 Reactome: R-HSA-192105 Reactome: R-HSA-193368 Reactome: R-HSA-193807 Reactome: R-HSA-1989781 Reactome: R-HSA-211976 Reactome: R-HSA-2151201 Reactome: R-HSA-2426168 Reactome: R-HSA-3214847 Reactome: R-HSA-381340 Reactome: R-HSA-3899300 Reactome: R-HSA-400206 Reactome: R-HSA-400253 Reactome: R-HSA-9018519 Reactome: R-HSA-9029569 Reactome: R-HSA-9623433 Reactome: R-HSA-9707564 Reactome: R-HSA-9707616 Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Coactivator 1 antibody Anti-Ncoa-1 antibody Anti-Class E Basic Helix-Loop-Helix Protein 74 antibody Anti-Bhlhe74 antibody Anti-Protein Hin-2 antibody Anti-Rip160 antibody Anti-Renal Carcinoma Antigen Ny-Ren-52 antibody Anti-Steroid Receptor Coactivator 1 antibody Anti-Src-1 antibody Anti-NCOA1 antibody Anti-BHLHE74 antibody Anti-SRC1 antibody |
Information sourced from Uniprot.org