Post Translational Modifications | H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Phosphorylated at Thr-11 by GSK3B during mitosis in prometaphase and dephosphorylated in telophase. Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. |
Function | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. |
Protein Name | Histone H1.5Histone H1aHistone H1bHistone H1s-3 |
Database Links | Reactome: R-HSA-140342Reactome: R-HSA-2559584 |
Cellular Localisation | NucleusChromosomeMore Commonly Found In HeterochromatinAssociates With Actively Transcribed Chromatin And Not Heterochromatin |
Alternative Antibody Names | Anti-Histone H1.5 antibodyAnti-Histone H1a antibodyAnti-Histone H1b antibodyAnti-Histone H1s-3 antibodyAnti-H1-5 antibodyAnti-H1F5 antibodyAnti-HIST1H1B antibody |
Information sourced from Uniprot.org