| Post Translational Modifications | Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Ubiquitinated. |
| Function | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
| Protein Name | Epidermal Growth Factor Receptor Substrate 15Protein Eps15Protein Af-1p |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideMembraneClathrin-Coated PitRecruited To The Plasma Membrane Upon Egfr Activation And Localizes To Coated PitsColocalizes With Ubqln1 In Ubiquitin-Rich Cytoplasmic Aggregates That Are Not Endocytic Compartments And In Cytoplasmic Juxtanuclear Structures Called AggresomesIsoform 2: Early Endosome MembraneColocalizes With Hgs On Bilayered Clathrin Coats On Endosomes |
| Alternative Antibody Names | Anti-Epidermal Growth Factor Receptor Substrate 15 antibodyAnti-Protein Eps15 antibodyAnti-Protein Af-1p antibodyAnti-EPS15 antibodyAnti-AF1P antibody |
Information sourced from Uniprot.org
