Western Blot analysis of 1 HeLa cell, 2 LPS 100ng/mL 30min treated, using primary antibody at 1:1000 dilution. Secondary antibody (STJS000791) was diluted at 1:10000

Anti-Phospho-DOK2-Tyr139 antibody (STJA0010029)

SKU:
STJA0010029
£48.00 - £252.00
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Phospho-Docking protein 2-Tyr139 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOK2
Gene ID: 9046
Uniprot ID: DOK2_HUMAN
Specificity: This antibody detects endogenous levels of p56 Dok-2 (Phospho Tyr139) Rabbit pAb at Human, Mouse
Immunogen: Synthesized peptide derived from human p56 Dok-2 (Phospho Tyr139)
Tissue Specificity Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Post Translational Modifications On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
Protein Name Docking Protein 2
Downstream Of Tyrosine Kinase 2
P56(Dok-2
Database Links Reactome: R-HSA-210993
Reactome: R-HSA-8853659
Alternative Antibody Names Anti-Docking Protein 2 antibody
Anti-Downstream Of Tyrosine Kinase 2 antibody
Anti-P56(Dok-2 antibody
Anti-DOK2 antibody

Information sourced from Uniprot.org

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