| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CREB1 |
| Gene ID: | 1385 |
| Uniprot ID: | CREB1_HUMAN |
| Specificity: | A synthetic phosphorylated peptide around S133 of human CREB1 (NP_604391.1). |
| Immunogen Sequence: | RPSYR |
| Post Translational Modifications | Stimulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion. CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1. Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119. Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization. |
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 1Creb-1Camp-Responsive Element-Binding Protein 1 |
| Database Links | Reactome: R-HSA-111931 P16220-1Reactome: R-HSA-111932 P16220-1Reactome: R-HSA-198693 P16220-1Reactome: R-HSA-199920 P16220-1Reactome: R-HSA-2151201 P16220-1Reactome: R-HSA-2197563 P16220-1Reactome: R-HSA-375165 P16220-1Reactome: R-HSA-400253 P16220-1Reactome: R-HSA-442720 P16220-1Reactome: R-HSA-442729 P16220-1Reactome: R-HSA-442742 P16220-1Reactome: R-HSA-5674400 P16220-1Reactome: R-HSA-881907 P16220-1Reactome: R-HSA-9022692 P16220-1Reactome: R-HSA-9022699 P16220-1Reactome: R-HSA-9022702 P16220-1Reactome: R-HSA-9022707 P16220-1Reactome: R-HSA-9031628 P16220-1Reactome: R-HSA-9609690 P16220-1Reactome: R-HSA-9616222 P16220-1Reactome: R-HSA-9634638 P16220-1Reactome: R-HSA-9660821 P16220-1Reactome: R-HSA-9664323 P16220-1Reactome: R-HSA-9707616 P16220-1Reactome: R-HSA-9824585 P16220-1Reactome: R-HSA-9856649 P16220-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 1 antibodyAnti-Creb-1 antibodyAnti-Camp-Responsive Element-Binding Protein 1 antibodyAnti-CREB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
