Anti-Phospho-c-Jun-T91 antibody [ARC1548] (STJ11102592)

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STJ11102592

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Host: Rabbit
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Short Description: Rabbit monoclonal anti-Phospho-c-Jun-T91 antibody is suitable for use in Western Blot and Immunohistochemistry.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: ARC1548
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: WB: 1:500-1:2000
IHC: 1:50-1:200
Uniprot ID: JUN_HUMAN
Gene ID: 3725
Gene Symbol: JUN
Immunogen: A phospho specific peptide corresponding to residues surrounding T91 of human c-Jun
Tissue Specificity Expressed in the developing and adult prostate and prostate cancer cells.
Post Translational Modifications Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7. Phosphorylated by CaMK4 and PRKDC.phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243.this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B.phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. Acetylated at Lys-271 by EP300.
Function Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGACGTCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells.
Protein Name Transcription Factor Ap-1
Activator Protein 1
Ap1
Proto-Oncogene C-Jun
V-Jun Avian Sarcoma Virus 17 Oncogene Homolog
P39
Database Links Reactome: R-HSA-1912408
Reactome: R-HSA-2559580
Reactome: R-HSA-2559582
Reactome: R-HSA-2871796
Reactome: R-HSA-450341
Reactome: R-HSA-5617472
Reactome: R-HSA-5687128
Reactome: R-HSA-6796648
Reactome: R-HSA-8862803
Reactome: R-HSA-8943724
Reactome: R-HSA-9018519
Reactome: R-HSA-9673324
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcription Factor Ap-1 antibody
Anti-Activator Protein 1 antibody
Anti-Ap1 antibody
Anti-Proto-Oncogene C-Jun antibody
Anti-V-Jun Avian Sarcoma Virus 17 Oncogene Homolog antibody
Anti-P39 antibody
Anti-JUN antibody

Information sourced from Uniprot.org

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