| Tissue Specificity | Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. |
| Post Translational Modifications | Acetylation at Lys-251 impairs antiapoptotic function. |
| Function | Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. |
| Protein Name | Apoptosis Inhibitor 5Api-5Antiapoptosis Clone 11 ProteinAac-11Cell Migration-Inducing Gene 8 ProteinFibroblast Growth Factor 2-Interacting FactorFifProtein Xagl |
| Cellular Localisation | NucleusCytoplasmMainly NuclearCan Also Be CytoplasmicIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Apoptosis Inhibitor 5 antibodyAnti-Api-5 antibodyAnti-Antiapoptosis Clone 11 Protein antibodyAnti-Aac-11 antibodyAnti-Cell Migration-Inducing Gene 8 Protein antibodyAnti-Fibroblast Growth Factor 2-Interacting Factor antibodyAnti-Fif antibodyAnti-Protein Xagl antibodyAnti-API5 antibodyAnti-MIG8 antibody |
Information sourced from Uniprot.org
