| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHLDA3 |
| Gene ID: | 23612 |
| Uniprot ID: | PHLA3_HUMAN |
| Immunogen Region: | 1-127 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human PHLDA3 (NP_036528.1). |
| Immunogen Sequence: | MTAAATATVLKEGVLEKRSG GLLQLWKRKRCVLTERGLQL FEAKGTGGRPKELSFARIKA VECVESTGRHIYFTLVTEGG GEIDFRCPLEDPGWNAQITL GLVKFKNQQAIQTVRARQSL GTGTLVS |
| Tissue Specificity | Widely expressed with lowest expression in liver and spleen. |
| Function | p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. |
| Protein Name | Pleckstrin Homology-Like Domain Family A Member 3Tdag51/Ipl Homolog 1 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Pleckstrin Homology-Like Domain Family A Member 3 antibodyAnti-Tdag51/Ipl Homolog 1 antibodyAnti-PHLDA3 antibodyAnti-TIH1 antibody |
Information sourced from Uniprot.org