| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:4000 IF/ICC:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHLDA2 |
| Gene ID: | 7262 |
| Uniprot ID: | PHLA2_HUMAN |
| Immunogen Region: | 1-152 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human PHLDA2 (NP_003302.1). |
| Immunogen Sequence: | MKSPDEVLREGELEKRSDSL FQLWKKKRGVLTSDRLSLFP ASPRARPKELRFHSILKVDC VERTGKYVYFTIVTTDHKEI DFRCAGESCWNAAIALALID FQNRRALQDFRSRQERTAPA APAEDAVAAAAAAPSEPSEP SRPSPQPKPRTP |
| Tissue Specificity | Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines. |
| Function | Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids. |
| Protein Name | Pleckstrin Homology-Like Domain Family A Member 2 Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene C Protein Imprinted In Placenta And Liver Protein Tumor-Suppressing Stf Cdna 3 Protein Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 3 Protein P17-Beckwith-Wiedemann Region 1 C P17-Bwr1c |
| Cellular Localisation | Cytoplasm Membrane Peripheral Membrane Protein |
| Alternative Antibody Names | Anti-Pleckstrin Homology-Like Domain Family A Member 2 antibody Anti-Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene C Protein antibody Anti-Imprinted In Placenta And Liver Protein antibody Anti-Tumor-Suppressing Stf Cdna 3 Protein antibody Anti-Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 3 Protein antibody Anti-P17-Beckwith-Wiedemann Region 1 C antibody Anti-P17-Bwr1c antibody Anti-PHLDA2 antibody Anti-BWR1C antibody Anti-HLDA2 antibody Anti-IPL antibody Anti-TSSC3 antibody |
Information sourced from Uniprot.org