| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PHC2 |
| Gene ID: |
1912 |
| Uniprot ID: |
PHC2_HUMAN |
| Immunogen Region: |
1-240 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PHC2 (NP_004418.2). |
| Immunogen Sequence: |
MTSGNGNSASSIAGTAPQNG ENKPPQAIVKPQILTHVIEG FVIQEGAEPFPVGRSSLLVG NLKKKYAQGFLPEKLPQQDH TTTTDSEMEEPYLQESKEEG APLKLKCELCGRVDFAYKFK RSKRFCSMACAKRYNVGCTK RVGLFHSDRSKLQKAGAATH NRRRASKASLPPLTKDTKKQ PTGTVPLSVTAALQLTHSQE DSSRCSDNSSYEEPLSPISA SSSTSRRRQGQRDLELPDM |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Protein Name | Polyhomeotic-Like Protein 2Hph2Early Development Regulatory Protein 2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusCo-Localizes With Samd7 In Nuclear Polycomb Bodies |
| Alternative Antibody Names | Anti-Polyhomeotic-Like Protein 2 antibodyAnti-Hph2 antibodyAnti-Early Development Regulatory Protein 2 antibodyAnti-PHC2 antibodyAnti-EDR2 antibodyAnti-PH2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
