| Function | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. |
| Protein Name | Phosphorylated Adapter Rna Export ProteinRna U Small Nuclear Rna Export Adapter Protein |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusNucleoplasmCajal BodyCytoplasmLocated In The Nucleoplasm And Cajal BodiesShuttles Between The Nucleus And The CytoplasmShuttles Between The Nucleoplasm And Cajal Bodies |
| Alternative Antibody Names | Anti-Phosphorylated Adapter Rna Export Protein antibodyAnti-Rna U Small Nuclear Rna Export Adapter Protein antibodyAnti-PHAX antibodyAnti-RNUXA antibody |
Information sourced from Uniprot.org
