| Host: | Mouse |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Retrotransposon-derived protein PEG10 (1-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 1B1C4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC 1:200-1:1000 IF 1:200-1:1000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PEG10 |
| Gene ID: | 23089 |
| Uniprot ID: | PEG10_HUMAN |
| Immunogen Region: | 1-120 aa |
| Specificity: | PEG10 Monoclonal Antibody detects endogenous levels of PEG10 protein. |
| Immunogen: | Purified recombinant fragment of PEG10 (aa1-120) expressed in E. Coli. |
| Post Translational Modifications | Isoform 1: Undergoes proteolytic cleavage. |
| Function | Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region. Involved in placenta formation: required for trophoblast stem cells differentiation. Involved at the immediate early stage of adipocyte differentiation. Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1. Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.additional evidences are however required to confirm this result. |
| Protein Name | Retrotransposon-Derived Protein Peg10 Embryonal Carcinoma Differentiation-Regulated Protein Mammalian Retrotransposon-Derived Protein 2 Myelin Expression Factor 3-Like Protein 1 Mef3-Like Protein 1 Paternally Expressed Gene 10 Protein Retrotransposon Gag Domain-Containing Protein 3 Retrotransposon-Derived Gag-Like Polyprotein Ty3/Gypsy-Like Protein |
| Cellular Localisation | Extracellular Vesicle Membrane Cytoplasm Nucleus Forms Virion-Like Extracellular Vesicles That Are Released From Cells Detected Predominantly In The Cytoplasm Of Breast And Prostate Carcinomas In Hepatocellular Carcinoma (Hcc) And B-Cell Chronic Lymphocytic Leukemia (B-Cll) Cells And In The Hep-G2 Cell Line |
| Alternative Antibody Names | Anti-Retrotransposon-Derived Protein Peg10 antibody Anti-Embryonal Carcinoma Differentiation-Regulated Protein antibody Anti-Mammalian Retrotransposon-Derived Protein 2 antibody Anti-Myelin Expression Factor 3-Like Protein 1 antibody Anti-Mef3-Like Protein 1 antibody Anti-Paternally Expressed Gene 10 Protein antibody Anti-Retrotransposon Gag Domain-Containing Protein 3 antibody Anti-Retrotransposon-Derived Gag-Like Polyprotein antibody Anti-Ty3/Gypsy-Like Protein antibody Anti-PEG10 antibody Anti-EDR antibody Anti-KIAA1051e antibody Anti-MAR2 antibody Anti-MART2 antibody Anti-MEF3L1 antibody Anti-RGAG3 antibody |
Information sourced from Uniprot.org