Immunohistochemistry analysis of PDYN in paraffin-embedded mouse brain using PDYN Rabbit polyclonal antibody (STJ28393) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-PDYN antibody (21-254) (STJ28393)

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STJ28393
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PDYN
Gene ID: 5173
Uniprot ID: PDYN_HUMAN
Immunogen Region: 21-254
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 21-254 of human PDYN (NP_077722.1).
Immunogen Sequence: DCLSRCSLCAVKTQDGPKPI NPLICSLQCQAALLPSEEWE RCQSFLSFFTPSTLGLNDKE DLGSKSVGEGPYSELAKLSG SFLKELEKSKFLPSISTKEN TLSKSLEEKLRGLSDGFREG AESELMRDAQLNDGAMETGT LYLAEEDPKEQVKRYGGFLR KYPKRSSEVAGEGDGDSMGH EDLYKRYGGFLRRIRPKLKW DNQKRYGGFLRRQFKVVTRS QEDPNAYSGELFDA
Post Translational Modifications The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Function Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin. Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
Protein Name Proenkephalin-B
Beta-Neoendorphin-Dynorphin
Preprodynorphin Cleaved Into - Alpha-Neoendorphin - Beta-Neoendorphin - Big Dynorphin
Big Dyn - Dynorphin A(1-17
Dyn-A17
Dynorphin A - Dynorphin A(1-13 - Dynorphin A(1-8 - Leu-Enkephalin - Rimorphin
Dynorphin B
Dyn-B
Dynorphin B(1-13 - Leumorphin
Dynorphin B-29
Database Links Reactome: R-HSA-111885
Reactome: R-HSA-202040
Reactome: R-HSA-375276
Reactome: R-HSA-418594
Cellular Localisation Secreted
Alternative Antibody Names Anti-Proenkephalin-B antibody
Anti-Beta-Neoendorphin-Dynorphin antibody
Anti-Preprodynorphin Cleaved Into - Alpha-Neoendorphin - Beta-Neoendorphin - Big Dynorphin antibody
Anti-Big Dyn - Dynorphin A(1-17 antibody
Anti-Dyn-A17 antibody
Anti-Dynorphin A - Dynorphin A(1-13 - Dynorphin A(1-8 - Leu-Enkephalin - Rimorphin antibody
Anti-Dynorphin B antibody
Anti-Dyn-B antibody
Anti-Dynorphin B(1-13 - Leumorphin antibody
Anti-Dynorphin B-29 antibody
Anti-PDYN antibody

Information sourced from Uniprot.org

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